代謝調控結構生物(wù)學研究組

> 課題組長(cháng)

　　　　李建戌，2005年畢業于山東師範大(dà)學，獲得(de)理(lǐ)學學士學位；2012年畢業于中國科學院上海生命科學研究院植物(wù)生理(lǐ)生态研究所，獲得(de)理(lǐ)學博士學位。2012年到2015年，先後于美(měi)國加州大(dà)學伯克利分(fēn)校和(hé)中國科學院植物(wù)生理(lǐ)生态研究所進行博士後研究。2015年11月(yuè)到2023年3月(yuè)在中國科學院分(fēn)子植物(wù)科學卓越創新中心/植物(wù)生理(lǐ)生态研究所曆任助理(lǐ)研究員(yuán)、副研究員(yuán)。于2023年4月(yuè)加入中國科學院分(fēn)子植物(wù)科學卓越創新中心辰山科研中心，擔任代謝調控結構生物(wù)學組青年課題組長(cháng)。曾獲賽諾菲-中國科學院上海生命科學研究院優秀青年人(rén)才獎，入選中國科學院青年創新促進會會員(yuán)及中國科學院特聘骨幹，主持中國博士後基金面上一等資助、國家自然科學基金的(de)青年基金和(hé)面上項目、上海市綠化(huà)和(hé)市容管理(lǐ)局科學技術項目等。研究方向爲植物(wù)天然産物(wù)代謝與結構生物(wù)學，聚焦植物(wù)代謝物(wù)的(de)合成及調控過程，研究關鍵酶的(de)催化(huà)和(hé)分(fēn)子調控機制，在Cell Research、PNAS、Progress in Lipid Research、Biochemical Journal、Plant Communications、Journal of Integrative Plant Biology和(hé)Frontiers in Plant Science等國際知名期刊發表論文25篇，申請及授權專利3項。

>研究領域

　　利用(yòng)蛋白晶體學、冷(lěng)凍電鏡技術、生物(wù)化(huà)學以及植物(wù)遺傳及生理(lǐ)學等技術方法，從事植物(wù)重要代謝物(wù)（萜類、黃(huáng)酮類化(huà)合物(wù)等）生物(wù)合成途徑中關鍵酶和(hé)調控因子及其複合體的(de)組裝、催化(huà)和(hé)調控機制研究，進而進行酶工程改造及合成生物(wù)學應用(yòng)。

>代表論文（^#第一作者，*通(tōng)訊作者）

　　1. Ni, Rong#; Niu, Meng#; Fu, Jie; Tan, Hui; Zhu, Tingting; Zhang, Jing; Lou, Hongxiang; Zhang, Peng; Li, Jianxu*; Cheng, Aixia*; Molecular and structural characterization of a promiscuous chalcone synthase from the fern species Stenoloma chusanum, Journal of Integrative Plant Biology, 2022, 64: 1935-1951.

　　2. Wang, Chengyuan#; Li, Jianxu#; Ma, Miaolian; Lin, Zhaozhu; Hu, Wenli; Lin, Wei*; Zhang, Peng*; Structural and Biochemical Insights Into Two BAHD Acyltransferases (AtSHT and AtSDT) Involved in Phenolamide Biosynthesis, Frontiers in Plant Science, 2021, 11: 610118.

　　3. Yao, Yuanfa#; Li, Jianxu#; Lin, Yinyan#; Zhou, Jiaqiang; Zhang, Peng*; Xu, Yingke*; Structural insights into phospholipase D function, Progress in Lipid Research, 2021, 81: 101070.

　　4. Niu, Meng#; Fu, Jie#; Ni, Rong; Xiong, Ruilin; Zhu, Tingting; Lou, Hongxiang; Zhang, Peng; Li, Jianxu*; Cheng Aixia*; Functional and structural investigation of chalcone synthases based on integrated metabolomics and transcriptome analysis on flavonoids and anthocyanins biosynthesis of the fern Cyclosorus parasiticus, Frontiers in Plant Science, 2021, 12: 757516.

　　5. Li, Jianxu#; Yu, Fang#; Guo, Hui; Xiong, Renxue; Zhang, Wenjing; He, Fangyuan; Zhang, Minhua; Zhang, Peng*; Crystal structure of plant PLDa1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D, Cell Research, 2020, 30(1): 61-69.

　　6. Chen, Qingwen#; Li, Jianxu#; Liu, Zhixi#; Mitsuhashi, Takaaki; Zhang, Yuting; Liu, Haili; Ma, Yihua; He, Juan; Shinada, Tetsuro; Sato, Tsutomu; Wang, Yong; Liu, Hongwei; Abe, Ikuro; Zhang, Peng*; Wang, Guodong*; Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases, Plant Communications, 2020, 1(5): 100051. (Cover story)

　　7. Liu, Zhifeng#; Li, Jianxu#; Sun, Yuwei#; Zhang, Peng*; Wang, Yong*; Structural Insights into the Catalytic Mechanism of a Plant Diterpene Glycosyltransferase SrUGT76G1, Plant Communications, 2020, 1(1): 100004.

　　8. Li, Jianxu#; Wang, Chengyuan#; Yang, Gaohua; Sun, Zhe; Guo, Hui; Shao, Kai; Gu, Yang; Jiang, Weihong*; Zhang, Peng*; Molecular mechanism of environmental D-xylose perception by a XylFII-LytS complex in bacteria, PNAS, 2017, 114(31): 8235-8240.

　　9. Fang, Xin#; Li, Jianxu#; Huang, Jinquan; Xiao, Youli; Zhang, Peng; Chen, Xiaoya*; Systematic identification of functional residues of Artemisia annua amorpha-4,11-diene synthase, Biochemical Journal, 2017, 474(13): 2191-2202. (Cover story)

　　10. Li, Jianxu#; Fang, Xin#; Zhao, Qin; Ruan, Juxin; Yang, Changqing; Wang, Lingjian; Miller, David J; Faraldos, Juan A; Allemann, Rudolf K; Chen, Xiaoya*; Zhang, Peng*; Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency, Biochemical Journal, 2013, 451(3): 417-426.

　　11. Song, Jiaojiao#; Fang, Xin#; Li, Chenyi; Jiang Yan; Li, Jianxu; Wu, Sheng; Guo, Juan; Liu, Yan; Fan, Hang; Huang, Yanbo; Wei, Yukun; Kong, Yu; Zhao, Qing; Xu, Jingjing; Hu, Yonghong; Chen, Xiaoya; Yang, Lei*; A 2-oxoglutarate-dependent dioxygenase converts dihydrofuran to furan in Salvia diterpenoids, Plant Physiology, 2022, 188: 1496-1506.

　　12. Xu, Jingjing#; Zhang, Xiaofan#; Yan, Jiang; Fan, Hang; Li, Jianxu; Li, Chenyi; Zhao, Qing; Yang, Lei; Hu, Yonghong; Martin, Cathie; Chen, Xiaoya*; A unique flavoenzyme operates in ubiquinone biosynthesis in photosynthesis-related eukaryotes, Science Advances, 2021, 7: eabl3594.

　　13. Chen, Qingwen; Li, Jianxu; Ma, Yihua; Yuan, Weiliang; Zhang, Peng; Wang, Guodong*; Occurrence and biosynthesis of plantsesterterpenes (C25), a new addition to terpene diversity, Plant Communications, 2021, 2: 100184.

　　14. Cui, Mengying; Lu, Anrui; Li, Jianxu; Liu, Jie; Fang, Yumin; Pei, Tianlin; Zhong, Xin; Wei, Yukun; Kong, Yu; Qiu, Wenqing; Hu, Yonghong; Yang, Jun; Chen, Xiaoya; Martin, Cathie; Zhao Qing*; Two types of O-methyltransferase are involved in biosynthesis of anticancer methoxylated 4’-deoxyflavones in Scutellaria baicalensis Georgi, Plant Biotechnology Journal, 2021, 20: 129-142.

　　15. Huang, Jinquan#; Fang, Xin#; Tian, Xiu; Chen, Ping; Lin, Jialing; Guo, Xiaoxiang; Li, Jianxu; Fan, Zhen; Song, Weimeng; Chen, Fangyan; Ahati, Ruzha; Wang, Lingjian; Zhao, Qing; Martin, Cathie; Chen, Xiaoya*; Aromatization of natural products by a specialized detoxification enzyme, Nature Chemical Biology, 2020, 16(3): 250-256.

　　16. Sun, Yuwei; Chen, Zhuo; Li, Jianxu; Li, Jianhua; Lv, Huajun; Yang, Jingya; Li, Weiwei; Xie, Dingan; Xiong, Zhiqiang; Zhang, Peng; Wang, Yong*; Diterpenoid UDP-Glycosyltransferases from Chinese Sweet Tea and Ashitaba Complete the Biosynthesis of Rubusoside, Molecular Plant, 2018, 11(10): 1308-1311. 

>申請及專利授權

1. 陳曉亞；李建戌；王淩健；洪高(gāo)潔；胡文利；阮菊新；楊長(cháng)青；毛穎波；一種酶活性提高(gāo)的(de)青蒿紫穗槐二烯合酶突變體及其應用(yòng)，CN201110285012.X.

2. 陳曉亞；王淩健；李建戌；一種新的(de)倍半萜合成酶及其用(yòng)途， CN201210025117.6.

3. 王勇；劉志鳳；孫雨(yǔ)偉；呂華軍；張鵬；李建戌；劉海利；李建華；陳卓；糖基轉移酶突變體及其應用(yòng)，201910917940.X.

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